基于细菌的益生菌清洁剂可以减少在常见的医院表面上形成干燥的生物膜
Richard Wormald1, Paul N Humphreys1, Christopher J Charles2
1Department of Biological and Geographical Sciences, University of Huddersfield, Huddersfield, UK.
MicrobiologyOpen
|December 22, 2023
概括
使用Bacillus细菌的益生菌清洁剂有效地防止医院表面的干燥生物膜形成. 这项研究显示,病原体生物负担减少了97.7%以上,提供了针对医疗保健相关感染的新策略.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 生物技术是生物技术.
背景情况:
- 医院表面上的干燥生物膜构成了与医疗保健相关的重大感染风险.
- 使用安全生物体的益生菌清洁剂,如Bacillus物种,为减少干燥生物膜生物负担提供了潜在的解决方案.
- 这些益生菌清洁剂的精确机制和有效性在很大程度上仍未被描述.
研究的目的:
- 开发和使用预防性干燥生物膜试验来评估Bacillus spp. 基于益生菌的清洁剂.
- 评估清洁剂在减少大肠杆菌和金黄色葡萄球菌的表面生物负担方面的有效性.
- 研究益生菌细菌在硬表面的殖民和作用机制.
主要方法:
- 通过使用钢,胺和陶表面建立了一种新的预防性干燥生物膜试验.
- 该试验评估了商业 Bacillus spp. 生物负担的大肠杆菌和金黄色葡萄球菌的减少. 益生菌清洁剂 益生菌清洁剂
- 使用共聚焦激光扫描显微镜可视化益生菌细菌的殖民和活动.
主要成果:
- 酸盐缓冲盐水对照在7天内成功生成干燥的生物膜.
- 益生菌清洁剂在所有测试的病原体类型和表面类型中防止了超过97.7%的干燥生物膜形成.
- 仅仅用益生菌治疗也显著减少了干燥生物膜的形成.
- 显微镜证实了益生菌细菌的发芽和殖民,表明形成了一层保护性表面层.
结论:
- 细菌种类. 细菌种类. 基于益生菌的清洁剂在防止在常见的医院硬表面上形成干燥的生物膜方面非常有效.
- 益生菌细菌积极殖民表面,可能会对病原体粘附和生物膜发育产生保护性屏障.
- 这项研究支持使用益生菌清洁剂作为一种可行的预防策略,以防止干燥生物膜产生的与医疗相关的感染.
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