对MRI特征和小儿多发性硬化症肠道微生物组的横截面研究
Feng Zhu1, Yinshan Zhao1, Douglas L Arnold2
1Department of Medicine (Neurology), The University of British Columbia, Vancouver, British Columbia, Canada.
Annals of clinical and translational neurology
|December 22, 2023
概括
像Tenericutes这样的肠道细菌与儿科多发性硬化症 (MS) 的更高的MRI损伤体积相关. 相反,Firmicutes和其他细菌与小儿多发性硬化症患者的较低病变负担有关.
科学领域:
- 微生物组研究的研究.
- 神经免疫学 神经免疫学
- 儿科神经学 儿科神经学
背景情况:
- 儿科发病多发性硬化症 (MS) 是一种使人虚弱的自身免疫性疾病,影响年轻人.
- 人们越来越认识到肠道微生物在神经炎症和多发性硬化症的发病过程中的作用.
- 了解肠道微生物组与MRI损伤负担等疾病标志物的关联对于儿科MS至关重要.
研究的目的:
- 调查肠道微生物组组成和MRI评估的小儿发病性MS的病变负担之间的关系.
- 为了确定与该种群中的病变体积相关的特定细菌分类 (类和属).
主要方法:
- 来自加拿大儿科消性疾病网络的儿科发作的MS参与者的横截面研究.
- 便样本的16S rRNA测序以分析肠道微生物组特征 (多样性,种群丰富性).
- 大脑MRI (T1和T2损伤体积) 在便收集后6个月内获得;使用回归模型进行统计分析.
主要成果:
- 在肠道微生物α多样性和病变体积之间没有发现显著的关联.
- 较高的Tenericutes的相对丰度与T1和T2损伤体积的增加有关.
- 病变体积的增加与更高的鲁米尼克洛斯特里和更低的科普罗可可克3和埃里西佩拉托克洛斯特里在属层面有关.
结论:
- 特定的肠道细菌类和属与儿科发病的MS的MRI病变负担有关.
- 这些发现表明肠道微生物群在儿科MS病理生理学的潜在作用.
- 对肠道微生物组调节的进一步研究可能为儿科MS提供新的治疗策略.
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