在第一线化疗后没有疾病进展的晚期胃癌中S-1维持疗法:回顾性分析
Luchun Li1, Ting Wang1, Zhijuan Wu1
1Department of Oncology, Chongqing University Cancer Hospital, P.R. China.
对于晚期胃癌患者,S-1维持疗法显著改善了与初始化疗后观察相比的生存结果. 虽然增加了一些毒性,如血小板缺血,S-1是耐受良好和有益的.
科学领域:
- 在瘤学瘤学.
- 胃肠道瘤学 胃肠道瘤学
- 癌症治疗方法 癌症治疗方法
背景情况:
- 晚期胃癌化疗后的最佳维持疗法仍未确定.
- 评估S-1维持疗法与观察对无进展和整体生存至关重要.
研究的目的:
- 为了比较S-1维持疗法的疗效和安全性与随访观察.
- 评估晚期胃癌患者的生存益处和毒性概况.
主要方法:
- 106名晚期胃癌患者的回顾性分析 (2018年1月至2021年12月).
- 患者在一线联合化疗后没有出现疾病进展.
- 主要终点:整体存活率 (OS) 和无进展存活率 (PFS);次要终点:与化疗相关的毒性.
主要成果:
- 与观察组相比,S-1维持疗法组的PFS和OS显著长 (p<0.001).
- 在子组分析中没有发现PFS或OS的显著差异 (p>0.05).
- 与S-1 (p<0.001) 观察到血小板缺血和手脚综合征的发病率增加,没有毒性相关的死亡.
结论:
- 在S-1维持疗法为晚期胃癌患者提供了显著的生存优势,在一线化疗后没有进展.
- 该疗法表现出良好的患者耐受性,尽管增加了特定毒性.
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