桃体状细胞癌患者的死亡率模式:一个基于人口的研究
Jia Wang1,2, Xiaolin Li1,2, Dongdong Niu1,2
1Clinical Research Service Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Frontiers in endocrinology
|December 22, 2023
概括
患有桃体状细胞癌 (TSCC) 的患者面临TSCC和第二原发性恶性瘤 (SPM) 的高死亡率. 一个新的预测模型有效地识别死亡风险,指导改善患者监测.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 流行病学 流行病学
背景情况:
- 状状细胞癌 (TSCC) 是死亡的一个重要原因.
- 第二次原发性恶性瘤 (SPMs) 也对TSCC患者的死亡率做出了重大贡献.
- 关于TSCC与SPM的相对死亡风险的数据有限.
研究的目的:
- 分析TSCC患者的死亡模式.
- 开发TSCC和SPM死亡风险的预测模型.
- 调查与TSCC特异性死亡 (TSD) 和SPM相关死亡相关的风险因素.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库用于培训和验证队列.
- 采用具有累积发病率函数的竞争风险方法.
- 应用了微型和灰色的比例分类危险模型.
- 开发并验证了5年和10年死亡风险的预后诺姆图.
主要成果:
- 在14530名TSCC患者中,TSCC是导致死亡的主要原因 (46.84%),其次是SPM (26.86%).
- 常见的SPM部位包括肺/支气管,喉和食道.
- 年龄,种族,婚姻状况,阶段,放射治疗和手术是死亡的独立风险因素.
结论:
- 患有TSCC的患者有显著的SPM发展的风险.
- 竞争的风险名录表在预测TSD和SPM相关死亡率方面表现出色.
- 对于TSCC幸存者的常规后续检查应包括SPM监测.
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