穿越电缆的旅程 穿越电缆的旅程
1Canadian Arthritis Patient Alliance, Bloomfield, Canada.
Journal of patient experience
|December 22, 2023
概括
患有严重类风湿性关节炎 (RA) 的患者面临着管理疼痛的挑战,包括长期使用阿片类药物相关的风险. 目前的政策限制了阿片类药物获取和逐渐减少的支持,突出了加拿大医疗保健资源的关键差距.
科学领域:
- 类风湿病学 类风湿病学
- 疼痛管理 疼痛管理
- 公共卫生政策 公共卫生政策
背景情况:
- 类风湿性关节炎 (RA) 带来了重大的长期管理挑战,影响了患者的生活质量.
- 类阿片类药物治疗已被用于管理严重的RA疼痛,但具有相当大的风险和长期依赖的担忧.
- 目前的阿片类药物危机导致了政策变化,限制了获取并鼓励逐渐减少.
研究的目的:
- 为了检查患者长期使用阿片类药物治疗严重类风湿性关节炎的经验.
- 为了突出患者在阿片类药物逐渐减少期间所面临的挑战.
- 为了确定在加拿大缺乏足够的支持系统,为患者接受阿片类药物逐渐减少.
主要方法:
- 定性患者叙述. 定性患者叙述.
- 对治疗挑战的回顾性审查.
- 分析政策对患者护理的影响.
主要成果:
- 严重的RA患者在诊断和长期药物疗效方面遇到了困难.
- 处方阿片类药物提供了暂时的缓解,但缺乏关于戒烟挑战的讨论.
- 目前的政策在加拿大没有足够的患者支持资源的情况下,会产生压力来逐渐减少阿片类药物.
结论:
- 长期阿片类药物治疗RA,虽然提供了生活质量的改善,但存在重大风险和戒断挑战.
- 阿片类药物政策的转变需要增加资金和资源,以便在逐渐减少期间为患者提供支持.
- 迫切需要提供全面的支持服务,以帮助患者在加拿大医疗保健系统内缓解阿片类药物使用.
相关概念视频
01:20Desensitization and Tachyphylaxis
1.7K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.7K
01:17Drug Dependence
1.0K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.0K
01:20Types of Damping
6.4K
If the amount of damping in a system is gradually increased, the period and frequency start to become affected because damping opposes, and hence slows, the back and forth motion (the net force is smaller in both directions). If there is a very large amount of damping, the system does not even oscillate; instead, it slowly moves toward equilibrium. In brief, an overdamped system moves slowly towards equilibrium, whereas an underdamped system moves quickly to equilibrium but will oscillate about...
6.4K
01:52Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
01:14Time Course of Drug Effect
2.1K
The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50...
2.1K
01:03Dose-Response Relationship: Overview
3.1K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
3.1K