猫下呼吸道疾病的猫对环境过敏原的反应
Birte F Hartung1, Ralf S Mueller1, Jana Gauss2
1LMU Small Animal Clinic, Ludwig Maximilian University of Munich, Munich, Germany.
Frontiers in veterinary science
|December 22, 2023
概括
患有猫下呼吸道疾病 (FLAD) 的猫的过敏测试显示了不同的结果. 皮内检测检测出了比血清检测更多的积极反应,环境过敏原的方法之间的一致性有限.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
背景情况:
- 猫性喘 (FA) 和猫性下呼吸道疾病 (FLAD) 是猫群中日益公认的疾病.
- 空气过敏原是可疑的触发物,但对自然存在的FLAD中的环境过敏原的研究是有限的.
- 了解过敏原敏感性对于诊断和管理至关重要.
研究的目的:
- 为了比较皮肤内检测 (IDT) 和血清过敏原特异性免疫球蛋白E (IgE) 检测 (SAT) 的诊断性能,在患有FLAD的猫身上.
- 调查过敏原暴露与患有FLAD的猫的测试结果之间的潜在关联.
- 评估IDT和SAT对各种环境过敏原的协议.
主要方法:
- 包括8只患有乙性炎症 (EI) 的猫,10只患有混合炎症 (MI),6只患有中性友炎症 (NI) 的猫和24只健康的猫 (HC).
- 通过支气管支气管洗液 (BLAF) 细胞学确定FLAD诊断和炎症类型.
- 对所有猫进行血清过敏原特异性IgE检测 (SAT);对患有FLAD的猫进行皮内检测 (IDT). 业主问卷收集了环境暴露数据.
主要成果:
- 与健康对照组 (83%) 相比,患有FLAD的猫在SAT测试中表现出较少的积极反应 (52%) (p=0.051).
- IDT检测到每只猫的积极反应明显高于SAT (p=0.001).
- 对于大多数过敏原来说,IDT和SAT之间的一致性很小,除了对英语植物和Alternaria alternata中等. 没有发现环境和过敏原反应之间的明显关联.
结论:
- 患有FLAD的猫的过敏测试结果需要与临床症状和个体患者因素一起仔细解释.
- 皮内检测可能比血清IgE检测更敏感,用于检测FLAD中的过敏原敏感性.
- 需要进一步的研究来澄清特定环境过敏原在猫下呼吸道疾病中的作用.
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