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羊群中Haemonchus contortus的多种药物耐药性 - - 它可以克服吗?
Michal Babják1, Alžbeta Königová1, Michaela Komáromyová1
1Institute of Parasitology of Slovak Academy of Sciences, 040 01 Košice, Slovak Republic.
Journal of veterinary research
|December 22, 2023
概括
在绵羊胃肠道线虫中,对阿尔本达和艾弗梅克的抗虫耐药性得到证实. 莱瓦米索尔显示出高疗效,为绵羊的寄生虫控制提供了有效的治疗选择.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 动物健康 动物健康
- 农场管理 农场管理
背景情况:
- 胃肠道线虫对绵羊健康和农场生产率构成重大威胁.
- 疑似减少甲虫疗效需要对寄生虫耐药性的研究.
- 虫耐药性对农场管理和经济可行性产生负面影响.
研究的目的:
- 在绵羊养殖场调查和证实胃肠道线虫对甲虫药物耐药性的研究.
- 评估阿尔本达 (ALB),艾弗梅克丁 (IVM) 和莱瓦米索尔 (LEV) 对这些寄生虫的疗效.
- 评估阿尔本达的替代剂量策略.
主要方法:
- 在体内进行了便卵数减少试验.
- 进行了体外卵化 (EHT) 和幼虫发育 (LDT) 试验.
- 绵羊接受了各种阿尔本达 (ALB) 剂量,艾弗梅克丁 (IVM),勒瓦米索尔 (LEV) 的治疗,或作为对照.
主要成果:
- 没有观察到标准,双重或分割的ALB剂量有显著的卵数减少.
- 在禁食羊中,ALB的疗效有限 (13.7-16.9%);IVM疗效在31.50~39.97%之间.
- 莱瓦米索尔 (LEV) 治疗导致所有动物在治疗后10天呈阴性卵子.
结论:
- 在Haemonchus contortus中证实对阿尔本达 (ALB) 和艾弗梅克丁 (IVM) 的耐药性.
- 替代的阿尔本达施用方法没有足够提高疗效.
- 莱瓦米索尔 (LEV) 已被证明是对被测试的寄生虫群体的有效杀虫剂治疗.
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