相关实验视频

Updated: Jul 7, 2025

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease

Published on: October 31, 2012

在G-CSF的一个小时内发生毛细血管泄漏综合征

Pallavi Agarwal¹, Aashima Pandhi¹, Amanda Strobel²

¹Department of Pediatrics (PA, AP), University of Florida at Ascension Sacred Heart Hospital, Pensacola, FL.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

|December 22, 2023

概括

毛细血管泄漏综合征 (CLS) 是一种罕见但严重的疾病. 这个案例突出了一个儿科患者,在花细胞殖民地刺激因子 (G-CSF) 治疗后迅速发展出CLS,强调需要及时识别和管理.

科学领域:

血液学血液学血液学
儿科重症监护儿科重症监护
瘤科支持性护理

背景情况:

毛细血管泄漏综合征 (CLS) 是一种与性休克和多创伤等严重疾病相关的已知的并发症.
在儿童和成人患者中,在各种细胞因子输注和骨髓移植后记录了CLS.
关于儿童群体中CLS的报告有限,特别是在花细胞殖民地刺激因子 (G-CSF) 给药后.

研究的目的:

报告一个罕见的儿科毛细血管泄漏综合征 (CLS) 病例.
为了描述儿童在粒细胞殖民地刺激因子 (G-CSF) 之后的CLS的快速发病.
强调及时诊断和G-CSF诱导的CLS的症状管理的重要性.

主要方法:

一个9岁的女性患者的病例报告.
在第一剂G-CSF后观察不良事件.
临床表现和治疗反应的文档.

主要成果:

患者在接受初始G-CSF剂量后60分钟内发生了CLS.
通过立即的症状治疗,成功控制了CLS症状.
这个案例增加了关于儿科CLS后G-CSF的有限文献.

结论:

颗粒细胞殖民地刺激因子 (G-CSF) 可以导致儿科患者的毛细血管泄漏综合征 (CLS).
快速识别和及时的症状管理对于G-CSF诱导的CLS的良好结果至关重要.
在接受G-CSF治疗的儿科患者中,对CLS需要进一步警.

更多相关视频

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

相关概念视频

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...