由abemaciclib引起的肺损伤导致乳腺癌导致大脑转移的停止治疗:一个病例报告
Hiroyasu Yamashiro1, Nao Morii2
1Department of Breast Surgery, Tenri Hospital, Nara, Tenri 632-8552, Japan. yamashiro.bcs@gmail.com.
World journal of clinical cases
|December 22, 2023
概括
本病例报告详细介绍了一名患有HER2阴性乳腺癌脑转移的患者,该患者最初对abemaciclib和letrozole有反应. 由于药物诱导的肺损伤,治疗被停止,这突出了管理不良事件的挑战.
科学领域:
- 在瘤学瘤学.
- 医学案例报告 病例报告
- 药理学 药理学是指药理学的学科.
背景情况:
- 在HER2阴性乳腺癌中,中枢神经系统 (CNS) 转移是一个重大的治疗挑战.
- 雌激素受体阳性,HER2阴性乳腺癌可以转移到大脑.
- 在这种患者群体中,中枢神经系统转移的有效治疗选择有限.
研究的目的:
- 在患有雌激素受体阳性,HER2阴性乳腺癌的患者中呈现一种独特的脑转移病例.
- 突出治疗反应和随后与abemaciclib和莱特醇治疗相关的不良事件.
- 为了强调在有限的治疗选择的背景下管理与治疗相关的毒性方面的挑战.
主要方法:
- 一个全面的案例摘要,一个60多岁的女性被诊断患有多重脑转移,11年后的原发性乳腺癌手术.
- 作为第三线全身疗法的abemaciclib和letrozole的使用.
- 通过成像和不良事件的评估来监测治疗反应,特别是药物诱导的肺损伤 (DILD).
主要成果:
- 患者在使用abemaciclib和letrozole的转移性脑病变中实现了近部分反应.
- 由于DILD的发展,Abemaciclib被停止使用,CT扫描证实了这一点.
- 在停止治疗后,DILD得到了缓解,但患者最终因进展性大脑转移而死亡.
结论:
- 响应性脑转移患者的不良事件的管理是具有挑战性的,因为缺乏替代疗法.
- 这一案例强调了治疗疗效,毒性和中枢神经系统参与的先进的HER2-阴性乳腺癌患者的患者结果之间的复杂相互作用.
- 需要进一步研究更安全,更有效的治疗策略来治疗这一亚组中大脑转移的病例.
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