在炎症性肠道疾病相关的结肠镜检查中,非聚乙烯糖醇肠道制剂的新兴空间:朝着更好的粘附性和可口性倾斜
Raffaele Pellegrino1, Antonietta Gerarda Gravina2
1Department of Precision Medicine, Hepatogastroenterology Division, University of Campania Luigi Vanvitelli, Naples 80138, Italy. raffaele.pellegrino@unicampania.it.
World journal of gastroenterology
|December 22, 2023
概括
新的研究表明,非聚乙烯糖醇 (PEG) 肠道制剂可能为接受结肠镜检查的炎症性肠病 (IBD) 患者提供更好的耐受性和患者偏好. 需要进一步的证据,但这些准备对那些缓解的人来说是有前途的.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 药理学 药理学是指药理学的学科.
背景情况:
- 炎症性肠病 (IBD) 需要频繁的结肠镜检查,以监测疾病活动,复发和癌症监测.
- 高质量的结肠镜取决于充分的肠道准备,目前的指导方针经常建议基于聚乙烯糖醇 (PEG) 的解决方案,由于广泛的安全数据.
- 从历史上看,高度,低体积的非PEG制剂 (例如酸/硫酸盐,口服硫酸盐溶液) 受到警告.
研究的目的:
- 审查有关在IBD患者中使用非PEG肠道制剂的新兴研究.
- 在IBD的背景下评估非PEG制剂的安全性,耐受性和患者偏好.
- 讨论IBD患者的肠道准备建议中的潜在范式转变.
主要方法:
- 在IBD患者队列中对非PEG肠道制剂的现有文献进行系统审查.
- 对临床试验数据的分析,比较非PEG和基于PEG的肠道制剂.
- 评估患者报告的结果,包括耐受性和偏好.
主要成果:
- 非PEG制剂在耐受性和患者偏好方面显示出潜在的有利安全性.
- 有证据表明,这些药物可能是IBD患者缓解或疾病得到良好控制的可行选择.
- 目前的数据虽然令人鼓舞,但对于所有IBD患者的普遍推是不够的.
结论:
- 非PEG肠道制剂对于特定的IBD患者群体来说是一个有希望的替代品,可能会提高坚持和程序质量.
- 需要进一步的研究来巩固非PEG制剂在不同IBD患者群体中的安全性和有效性.
- 在IBD管理中,转向个性化肠道准备策略的转变可能在地平线上.
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