探讨身体构成和青春期相关风险因素对青少年异常脊椎病的因果关系:一项双样本的孟德尔随机化研究
Faegheh Ghanbari1, Nao Otomo2,3, Isabel Gamache1
1Research Center of the Sainte-Justine University Hospital University of Montreal Montreal Quebec Canada.
JBMR plus
|December 22, 2023
概括
在大型研究中,青少年异常学脊椎病 (AIS) 风险与身体组成或青春期因素没有因果关系. 然而,较高的骨矿物质密度 (BMD) 可能会保护欧洲女性患有AIS,尽管这一效应受到BMI和维生素D水平的影响.
科学领域:
- 遗传学和流行病学
- 肌肉骨健康 肌肉骨健康
- 儿科疾病 儿科疾病
背景情况:
- 青少年异常脊椎病 (AIS) 是一种常见的儿科肌肉骨疾病,其危险因素不明.
- 观察性研究表明,与身体成分和青春期存在潜在联系,但缺乏因果关系的证据.
研究的目的:
- 通过使用孟德尔随机化 (MR) 调查身体组成和青春期相关暴露和AIS风险之间的因果关系.
- 在欧洲和亚洲人口中分析这些关联.
主要方法:
- 采用了两个样本的门德尔随机化 (MR) 研究设计.
- 使用大型全基因组关联研究 (GWAS) 对暴露 (BMI,腰比,肌肉质量,肥胖,BMD,25OHD,初潮年龄,青春期生长) 和AIS风险.
- 应用了反向变异加权 (IVW) 和变性敏感的MR方法.
主要成果:
- 总体MR分析没有发现被调查的风险因素和AIS之间存在显著的因果关系.
- 在欧洲女性中观察到骨矿物质密度 (BMD) 对AIS风险的潜在保护性因果作用.
- 在调整了BMI,体脂质量和25-氧维生素D (25OHD) 后,这种BMD相关性减弱了.
结论:
- 该研究没有发现身体组成或与青春期相关的因素在青少年异常学脊椎病 (AIS) 风险中的因果关系.
- 建议较高的骨矿物质密度 (BMD) 对欧洲女性AIS风险的潜在保护作用,但这被BMI,体脂质量和25OHD修改.
- 需要更大的GWAS来探索这些暴露对AIS的潜在小影响.
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