定量和定性肌肉参数与老年女性第二次关节骨折风险的关联:前性队列研究
Wenshuang Zhang1,2, Yufeng Ge3, Yandong Liu1
1Department of Radiology, Beijing Jishuitan Hospital Capital Medical University Beijing China.
JBMR plus
|December 22, 2023
概括
定量肌肉密度,而不是定性分级,更好地预测老年女性的第二次关节骨折. 关节中和最小肌肉密度显示在预测随后的关节骨折方面具有边界意义.
科学领域:
- 老年学是一门学科.
- 整形外科 整形外科 整形外科
- 放射学 放射学是一门学科.
背景情况:
- 老年妇女有第二次关节骨折的高风险,这会带来严重的后果.
- 早期识别有风险的个体对于预防策略至关重要.
研究的目的:
- 为了比较第二次关节骨折的定性和定量肌肉参数的预测能力,在女性中具有先前的关节骨折.
- 确定用于第二次关节骨折风险评估的可靠标记物.
主要方法:
- 对206名首次关节骨折的女性进行前性研究.
- 部CT扫描评估了肌肉脂肪透 (Goutallier分类) 和定量肌肉参数 (横截面积,部最大和部中等/最小的密度).
- 测量了对侧大腿骨的区域骨矿物质密度 (aBMD);考克斯模型分析了第二次关节骨折风险.
主要成果:
- 质量性Goutallier分类 (严重等级除外) 并没有显著预测第二次关节骨折.
- 在协变性调整 (HR 1.44-1.46) 后,定量性 gluteus medius/minimus 肌肉密度是显著的预测因素.
- 这种关联即使在调整为股骨部aBMD (HR 1.43,p=0.057) 之后也仍然具有边缘显著性.
结论:
- 定量肌肉指标,特别是关节肌肉密度,比定性评估更有效地预测老年女性的第二次关节骨折.
- 关节中间/最小肌肉密度可以作为第二次关节骨折风险的边界独立预测因素,即使考虑到骨密度.
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