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帕金森病中的布拉迪基尼西亚运动特征的解剖学基质和连接性,在亚体内核深度大脑刺激后

Min Jae Kim^1,2,3, Yiwen Shi¹, Jasmine Lee¹

¹Movement Disorders Division, Department of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.

Brain communications

|December 22, 2023

概括

研究人员在帕金森症勃拉基尼西亚中绘制了振幅和频率的变化,使用亚体内核深度大脑刺激. 亚thalamic核内的不同解剖区域与特定的运动缺陷相关,有助于个性化治疗的发展.

科学领域:

神经科学是一个神经科学.
神经学神经学
生物医学工程生物医学工程

背景情况:

帕金森症勃拉迪基尼西亚是一种复杂的运动症状,其特点是运动频率减慢,幅度降低和动作失律.
了解这些布拉迪基尼西亚成分的独特神经基质对于开发有针对性的个性化疗法至关重要.
脑下核深度大脑刺激 (STN-DBS) 是一种常见的治疗方法,但它对布拉迪基尼西亚成分的确切影响需要进一步阐明.

研究的目的:

调查在接受STN-DBS的帕金森病患者的亚thalamic核内的振幅和频率缺陷的差异定位.
为了将运动变化与激活的组织体积和功能连接模式相关联.
为了确定布拉迪基尼西亚的振幅和频率元件的独特解剖基质.

主要方法:

利用光学运动传感器在15名帕金森病患者的STN-DBS"开启"和"关闭"过程中量化手部运动幅度和频率.
通过使用统一帕金森病评分表第三部分 (UPDRS-III) 盲目评估布拉迪基尼西亚严重程度.
将振幅和频率的变化映射到STN内估计的激活组织体积,并分析了全脑功能连接.

主要成果:

运动幅度的STN-DBS诱导的变化与右手和左手抓握的UPDRS-III分数负相关.
运动频率的变化与两只手的幅度变化有负相关.
幅度和频率缺陷在STN的前中后侧轴上呈现出明显的地形表征,有重叠和不重叠的区域.

结论:

在帕金森症勃拉迪基尼西亚的运动幅度和频率变化在亚thalamic 核内有明显的表现.
这些独特的运动部件与特定的解剖基质和全脑功能连接模式有关.
这些发现支持基于个人布拉迪基尼西亚成分局部化开发针对帕金森病的针对网络的个性化疗法.

关键词:

帕金森病是帕金森氏症的一种疾病.布拉迪基尼西亚是什么意思深度大脑刺激刺激大脑亚体的细胞核.

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