低肌肉强度与代谢功能障碍相关的脂肪肝疾病的关联:一项全国性研究
Gyu Bae Lee1, Youn Huh2, Sang Hyun Lee3
1Department of Family Medicine, Korea University College of Medicine, Seoul 02841, South Korea.
World journal of gastroenterology
|December 22, 2023
概括
低肌肉强度与韩国成年人代谢功能障碍相关的脂肪肝疾病 (MAFLD) 和肝纤维化风险较高有关. 保持肌肉力量可能对预防MAFLD进展至关重要.
科学领域:
- 代谢健康 代谢健康
- 肝脏疾病研究 肝脏疾病研究
- 肌肉骨健康 肌肉骨健康
背景情况:
- 关于肌肉强度与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 之间的联系的证据有限.
- 了解这种关联对于公共卫生至关重要,特别是在老龄化人口中.
研究的目的:
- 在韩国普通人口中调查肌肉力量和MAFLD之间的关系.
- 评估低肌肉强度是否与MAFLD患者肝纤维化风险增加有关.
主要方法:
- 这是一项从2015年至2018年对31,649名韩国成年人 (≥19岁) 的全国性横截面研究.
- 用相对握手强度来评估肌肉强度,分为性别特定的四分位数.
- 使用多变量逻辑回归分析来确定赔率比率 (OR) 和95%置信区间 (95%CI).
主要成果:
- 29.3%的参与者患有MAFLD,较低肌肉强度四分位数的患病率更高 (P < 0.001).
- 与较高四分位数相比,肌肉强度最低四分位数的人患MAFLD (OR=1.92) 和严重肝纤维化 (OR=1.83) 的风险明显更高.
- 在各种子组中观察到肌肉强度和MAFLD风险之间存在剂量依赖的逆相关性.
结论:
- 低肌肉强度与韩国成年人患MAFLD风险增加有显著关联.
- 肌肉力量的减少也与被诊断为MAFLD的患者中肝纤维化更高的可能性有关.
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