预测在实体器官移植之前和之后的2型糖尿病风险,使用丹麦队列中的多基因分数
Quenia Dos Santos1, Preston Leung1, Christian W Thorball2,3
1Centre of Excellence for Health, Institut Roche, Immunity and Infections (CHIP), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Frontiers in molecular biosciences
|December 22, 2023
概括
多基因风险评分 (PRS) 预测在实体器官移植 (SOT) 患者中进行移植前的2型糖尿病 (T2DM). 然而,PRS并没有改善移植前T2DM或移植后糖尿病 (PTDM) 的预测.
科学领域:
- 遗传学和精准医学 遗传学和精准医学
- 移植免疫学 移植免疫学
- 代谢疾病 代谢疾病
背景情况:
- 2型糖尿病 (T2DM) 是一种复杂的疾病,受遗传和环境因素的影响.
- 固体器官移植 (SOT) 接受者患糖尿病的风险增加.
- 预测移植前T2DM和移植后糖尿病 (PTDM) 对于患者管理至关重要.
研究的目的:
- 评估多基因风险评分 (PRS) 对SOT患者移植前T2DM和PTDM的预测效用.
- 为了比较单独的PRS与与非遗传风险得分相结合的PRS的性能.
- 评估PRS在识别高风险T2DM的SOT接受者的临床实用性.
主要方法:
- 使用非遗传风险得分和PRS,开发了后勤回归模型.
- 用接收机操作员特征 (ROC) 曲线来比较模型性能.
- 患者在移植前和移植后三次间隔 (0-45,46-365,>365天) 评估T2DM.
主要成果:
- 较高的PRS显着与移植前T2DM的几率增加有关.
- 将PRS与非遗传风险得分相结合并没有改善移植前T2DM的预测准确性.
- 在任何移植后的时期中,PRS都没有提高PTDM的预测.
结论:
- 多基因风险与SOT接受者的移植前T2DM有关,但与PTDM无关.
- 目前的PRS模型对于预测SOT患者T2DM的临床实用性有限.
- 非遗传或独特的遗传因素可能有助于PTDM的发展.
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