外围中性粒细胞和与氧化压力相关的分子用于预测喘的严重程度:基于多维评估的横截面研究
Ruolin Mao1,2, Zhilong Jiang1, Zhihui Min3
1Department of Respiratory and Critical Care Medicine, Shanghai Institute of Respiratory Disease, Zhongshan Hospital, Fudan University, Shanghai, China.
Frontiers in medicine
|December 22, 2023
概括
严重的喘与中性粒细胞和氧化应激标志物的增加有关. 周围血液中性粒细胞和8-iso-PGF2α显示为预测喘严重性的生物标志物,有助于开发预测模型.
科学领域:
- 肺部病理学 肺部病理学
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 喘的严重程度与复杂的病理生理变化有关.
- 氧化应激在喘恶化和进展中起着重要作用.
- 确定可靠的喘严重性的生物标志物对于有效的管理至关重要.
研究的目的:
- 为了研究喘严重程度和中性粒细胞数量之间的相关性.
- 探索氧化应激标志物在严重喘中的作用.
- 使用已识别的生物标志物开发喘严重程度的预测模型.
主要方法:
- 招募了67名喘患者 (25名严重,42名不严重).
- 收集临床数据,诱导液和外周血液样本.
- 分析肺功能,氧化应激分子 (ROS,8-iso-PGF2α),中性粒细胞计数和HDAC2表达/活性.
- 应用ROC分析和多变量逻辑回归用于生物标志物识别和模型开发.
主要成果:
- 严重喘患者的中性粒细胞数量和百分比较高.
- 在严重的喘中观察到中性粒细胞和周围血液中的8-iso-PGF2α中的ROS升高.
- 在严重喘患者的外周血液单核细胞 (PBMC) 中发现了减少的HDAC2蛋白活性.
- 开发了一个结合中性粒细胞和8-iso-PGF2α的预测模型.
结论:
- 增加的氧化应激是严重喘的特征.
- 外周血液中性粒细胞和8-iso-PGF2α是预测喘严重程度的潜在生物标志物.
- 一个新的预测模型提供了对喘严重程度的准确评估.
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:26Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:20Asthma: Pathogenesis and Management
411
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
411
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K