腹腔大动脉封闭和心脏和大脑的炎症影响
Jun Xu1, Sijie Li1, Alexandra Wehbe2,3
1Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital, Center of Stroke, Beijing Institute of Brain Disorder, Capital Medical University, Beijing 100053, China.
Mediators of inflammation
|December 22, 2023
概括
腹腔大动脉封闭 (AAO) 会导致血清,大脑和心脏的炎症,但不会导致细胞亡或细胞亡. 在AAO中缺血时间会影响远处器官的炎症标志物和氧化应激.
科学领域:
- 心血管科学 心血管科学
- 神经学 神经学
- 器官受伤器官受伤器官受伤器官受伤器官
背景情况:
- 腹腔大动脉封闭 (AAO) 是一种常见的疾病,导致远处器官的缺血/反 (I/R) 损伤.
- 了解AAO对心脏和神经组织的影响对于管理患者的治疗结果至关重要.
研究的目的:
- 为了研究心脏和神经组织中AAO诱导的I / R损伤.
- 确定AAO期间缺血时间如何影响活性氧物种 (ROS) 生产和心脏,大脑和血清中的炎症标志物.
主要方法:
- 雄性C57BL/6小鼠接受了假冒手术或AAO,闭塞时间从1小时到4小时,随后进行24小时的再输液.
- 血清,海马和左心室组织被生物化学和本病理学分析.
主要成果:
- 在心脏或神经组织中,AAO没有诱导显著的细胞死亡或细胞亡.
- 在血清和海马体中观察到麦隆迪阿尔代 (MDA) 和乳酸脱酶 (LDH) 的增加.
- AAO改变了炎症标志物概况,降低了抗氧化能力和抗炎因素,同时增加了血清,海马体和/或心脏中的炎症标志物.
结论:
- 在心脏或神经组织中,AAO不会诱导亡或亡.
- AAO会在血清,大脑和心脏中引发严重的炎症.
- 炎症的程度受主动脉封闭的持续时间的影响.
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