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丁甲基甘氨酸通过改善通过肠道循环雌激素水平缓解代谢功能障碍相关的脂肪肝疾病 葡萄球菌
Hong Yao1, Yan Hu1, Haibing Tong1
1Jiangsu Institute of Poultry Science, Yangzhou, Jiangsu 225125, China.
Journal of agricultural and food chemistry
|December 22, 2023
概括
食二甲基甘氨酸 (DMG) 通过减少脂肪肝和增强蛋黄脂质来改善产母的健康. 通过肠道细菌,DMG增加雌激素 (E2),促进脂质运输和缓解肝脏问题.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 食二甲基甘氨酸 (DMG) 曾经对晚产母的蛋产量和脂肪沉积有好处.
- 脂肪肝疾病和脂质运输受损是产母营养方面的担忧.
- 肠道雌激素代谢细菌 (EBM) 具有β-葡萄糖酶 (GUS) 活性调节循环雌激素 (E2).
研究的目的:
- 研究食DMG减轻产母脂肪肝疾病的机制.
- 确定肠道细菌,雌激素和GUS活动在DMG影响中的作用.
- 阐明DMG如何影响肝脂运输和黄脂沉积.
主要方法:
- 用0.1%的DMG补充给产母的食.
- 分析血液中的E2水平,囊中GUS活动,以及细菌的丰富性 (特别是葡萄球菌).
- 使用脂肪化LMH细胞模型研究E2对肝脂沉积和运输的影响.
主要成果:
- 饮食DMG减轻了脂肪肝疾病和增强了黄黄脂沉积.
- DMG增加了循环中的E2水平,EBM中的葡萄球菌的丰富性,以及体GUS活动.
- 具有GUS活性的葡萄球菌被确定为DMG的目标.
- 已经证明,E2在肥胖LMH模型中促进肝脂运输.
结论:
- 通过调节Staphylococcus介导的E2水平,DMG可以缓解产母的肝脂运输限制.
- 这种机制有助于减轻脂肪肝疾病,并改善蛋黄中的脂质沉积.
- DMG的作用涉及饮食,肠道微生物群,雌激素和宿主脂质代谢之间的复杂相互作用.
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