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身体质量指数,脆弱性和心力衰竭的结果与保存的喷射分数

Wenjie Li¹, Zhiyan Wang¹, Chang Hua¹

¹Department of Cardiology, Anzhen Hospital, Beijing, China.

ESC heart failure

|December 22, 2023

概括

脆弱性增加了心力衰竭的不良事件与保存的喷射分数 (HFpEF) 患者,无论身体质量指数 (BMI). 然而,BMI与虚弱风险之间的关系在美国和中国人口之间有所不同.

科学领域:

心脏病学心脏病学
老年病的医生老年病的医生
公共卫生公共卫生

背景情况:

身体质量指数 (BMI),虚弱性和心力衰竭患者的不良临床事件之间的相互作用与保存的喷射分数 (HFpEF) 在不同人群中尚不清楚.
以前的研究还没有充分比较西方与东方队列中的这些关联.

研究的目的:

为了比较美国和中国患者与HFpEF的BMI,虚弱和临床不良事件的关联.
调查BMI分布的差异及其与心脏功能保存心脏衰竭与阿尔多抗体治疗 (TOPCAT) 美国队列和心脏衰竭患者结果登记 (HERO) 中国队列之间的脆弱性关系.

主要方法:

利用了来自1715名美国患者 (TOPCAT) 和1487名中国患者 (HERO) 的HFpEF.数据.
采用多变量受限立方线逻辑回归来评估BMI-脆弱性关系和Cox对结果关联的比例危险模型.
分析了包括HF住院,堕胎突然死亡,心血管死亡和全因死亡率在内的主要结果.

主要成果:

与中国患者相比,美国患者的平均BMI高 (33.9 vs. 24 kg/m2),中度至重度虚弱的患病率高 (72.3% vs. 52.9%).
在美国队列中,随着BMI的上升,虚弱风险增加,而在中国队列中没有观察到这种关联.
虚弱与复合结果的风险增加,所有原因的死亡率和两个队列中的HF住院风险显著相关,BMI类别的效果大小相似.

结论:

美国和中国HFpEF人群之间的BMI分布和BMI-脆弱性关系存在显著差异.
虚弱是不同BMI水平和种族的HFpEF患者不良临床结果的一致预测指标.
这些发现强调了评估HFpEF管理中的脆弱性的重要性,无论BMI或地理来源如何.

关键词:

体重指数 (Body Mass Index) 是一个指数.脆弱性脆弱性脆弱性心力衰竭与保存的喷射分数的心脏衰竭种族种族种族种族

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