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Updated: Aug 17, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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结肠直肠癌的特定遗传差异通过下一代测序使用多基因面板

Ahmet Rencuzogullari, Atil Bisgin, Kivilcim Eren Erdogan

    Annali italiani di chirurgia
    |December 22, 2023
    PubMed
    概括

    下一代测序 (NGS) 在结直肠癌中发现了可操作的突变,在右结肠中频率更高. 这种基因组分析有助于预测耐药性和个性化治疗策略.

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    Tumor Progression02:07

    Tumor Progression

    Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
    Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...