布罗卢齐祖马布在与年龄相关的黄斑新血管化 (BRAIN研究):有效性,光学连贯性断层扫描生物标志物和安全性概况
Supriya Dabir1, Arthi Mohankumar, Manoj G Khatri
1Rajan Retina Foundation, Rajan Eye Care Hospital, Chennai, Tamil Nadu, India.
Indian journal of ophthalmology
|December 22, 2023
概括
针对神经血管与年龄相关的黄斑变性 (nAMD) 和异常多重型冠状血管病变 (IPCV) 的布罗卢齐祖马布注射显示,视力敏度显著改善,视网膜厚度降低. 这种新的抗血管内皮生长因子 (抗VEGF) 疗法可能允许在更长的时间间隔内进行更少的注射.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理疗法 药理疗法 药理疗法
背景情况:
- 布罗卢齐祖马布是一种新兴的抗血管内皮生长因子 (抗VEGF) 疗法.
- 它用于治疗新血管与年龄相关的黄斑变性 (nAMD) 和异常多重型冠状血管病变 (IPCV).
研究的目的:
- 评估brolucizumab在患有nAMD和IPCV的患者中的疗效和安全性.
- 为了评估视觉敏度,视网膜厚度和治疗后液体水平的变化.
主要方法:
- 一项回顾性,干预性研究包括接受内勃鲁西祖马布治疗的前治疗和治疗切换患者.
- 测量结果包括最佳校正的视力敏度 (BCVA),中央子场厚度 (CST) 和通过光谱域光学连贯断层扫描 (SD-OCT) 的流体水平.
主要成果:
- 在以前未接受过治疗的患者中观察到BCVA的显著改善和CST的减少 (P <0.05).
- 平均CST从582.92±233.11μm下降到474.06±252.89μm. 这是一个很大的变化.
- 38%的患者在一次注射后实现了完全的脑下超反射物质 (SHRM) 解析,后续注射间隔越来越长.
结论:
- 布罗卢齐祖马布在nAMD和IPCV中显示出显著的视觉和解剖学改善的潜力.
- 该疗法可以减少注射频率和延长治疗间隔.
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