微生物群组成和益生菌补充剂对睡眠质量-一个系统性审查和元分析
Daniele Santi1,2,3, Valentina Debbi1, Francesco Costantino1,2
1Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41126 Modena, Italy.
Clocks & sleep
|December 22, 2023
概括
这项研究发现,在睡眠障碍中,肠道微生物群的多样性没有显著差异. 然而,益生菌补充改善了自我评估的睡眠质量,这表明肠道健康在睡眠障碍中的潜在治疗作用.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
背景情况:
- 肠道微生物群 (GM) 通过微生物群-肠道-大脑轴影响中枢神经系统,可能会影响睡眠/清醒周期.
- 肠道失生症越来越多地与睡眠障碍有关,益生菌被提出作为一种潜在的干预措施.
- 目前关于转基因和睡眠障碍以及益生菌疗效的证据有限且不一致.
研究的目的:
- 进行量化元分析,评估睡眠障碍患者的肠道微生物群组成.
- 评估益生菌在治疗睡眠障碍方面的有效性.
主要方法:
- 在2022年7月之前以英语出版的人类研究的系统审查.
- 对睡眠障碍患者与健康对照群的肠道微生物群多样性 (α-多样性) 的分析.
- 对益生菌干预对睡眠质量和白天嗜睡的影响的元分析.
主要成果:
- 在睡眠障碍患者和健康对照人群之间没有观察到肠道微生物群的α多样性的显著差异.
- 益生菌补充剂显著降低了匹兹堡睡眠质量指数 (PSQI) 的得分,表明自我评估的睡眠质量有所改善.
- 在益生菌和安慰剂组之间的爱普沃思睡眠度量 (ESS) 评分中没有发现显著差异.
结论:
- 根据目前的数据,肠道微生物群的多样性在睡眠障碍中似乎没有显著改变.
- 益生菌有望改善主观睡眠质量,正如PSQI得分所表明的那样.
- 需要进一步的研究,考虑到科学文献中数据报告的异质性.
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