使用前向散射光测量的早期血液凝块检测并不优于三角洲压力测量
Anna Fischbach1, Michael Lamberti2, Julia Alexandra Simons1
1Department of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Biosensors
|December 22, 2023
概括
前向散射光 (FSL) 测量未能在体外膜氧化器电路中检测出早期血栓. 当前压力监测仍然是ECMO治疗期间识别显著血栓形成的黄金标准.
科学领域:
- 生物医学工程 生物医学工程
- 医疗器械技术 医疗器械技术
- 心血管研究研究心血管研究
背景情况:
- 体外膜氧化器 (ECMO) 中的血栓形成是一个关键的并发症,导致危及生命的血栓栓塞.
- 目前的临床实践依赖于压差 (ΔP) 监测,无法检测早期或小血块.
- 对于能够在ECMO治疗期间早期检测血液凝块的敏感传感器存在未满足的需求,以减轻患者的风险.
研究的目的:
- 评估前向散射光 (FSL) 测量在ECMO电路中早期检测血块的有效性.
- 为了比较FSL测量的灵敏度与目前用于血栓检测的压力监测 (ΔP) 的黄金标准.
主要方法:
- 使用一个带有定制室的体外试验电路,循环肝素化人体全血.
- 前向散射光 (FSL) 的测量是使用战略位置的LED和光电极管进行的.
- 压力监测器记录了整个试验室的压力差异 (ΔP),以检测血栓形成.
主要成果:
- 尽管对LED放置进行了修改,但FSL测量无法在体外ECMO电路中可靠地检测血块.
- 压力监测 (ΔP) 在所有11个独立的实验运行中成功确定了显著的凝块形成.
- 在这种ECMO模型中,FSL测量被发现低于压力监测用于检测血栓.
结论:
- 前向散射光 (FSL) 测量不是ECMO电路中早期检测血块的合适方法.
- 当前压力监测 (ΔP) 仍然是ECMO治疗期间检测显著血栓形成的临床标准.
- 需要进一步的研究来开发用于ECMO中早期发现血栓的新型传感器,以提高患者的安全性.
相关概念视频
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