在西伯利亚人口中对SARS-CoV-2的流行前交叉反应性免疫力
Olga N Shaprova1, Daniil V Shanshin1,2, Evgeniia A Kolosova1,2
1State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia.
Antibodies (Basel, Switzerland)
|December 22, 2023
概括
来自俄罗斯的流行前血清样本显示了对SARS-CoV-2蛋白质的交叉反应性抗体,这表明先前存在的免疫力可能会影响COVID-19的严重程度. 这一发现可能有助于了解大流行病毒的出现和疾病的进展.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行病在2019年底出现.
- 关于先前存在的免疫对疾病严重程度的影响仍然存在问题.
- 了解大流行前的免疫反应性可能会为大流行病毒的出现提供见解.
研究的目的:
- 在疫情爆发之前,评估针对SARS-CoV-2核体和尖端蛋白的现有抗体.
- 评估这些抗体的病毒中和能力.
- 探索交叉免疫在COVID-19结果中的潜在作用.
主要方法:
- 分析了2019年10月至11月在俄罗斯西伯利亚收集的799个血清样本.
- 使用酶链接免疫吸收试验 (ELISA) 与复合SARS-CoV-2抗原 (核体,S蛋白碎片,RBD) 的使用.
- 在细胞培养中测试针对SARS-CoV-2的中和活性.
主要成果:
- 观察到对S蛋白碎片 (22.9%) 和核蛋白 (33.8%) 的显著反应性.
- 16.2%的血清对两种抗原都有反应.
- 只有5个血清显示出IgG对RBD;没有一个表现出对SARS-CoV-2的中和活性.
结论:
- 来自研究的俄罗斯人口的流行前血清表现出对SARS-CoV-2的交叉反应性幽默免疫力.
- 孤立的种群显示出较低的交叉反应血清水平.
- 需要进一步的研究来确定这种交叉免疫对COVID-19流行率和死亡率的影响.
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