在患有2型糖尿病的老年人中,sarcopenia和低血糖控制之间的关联
Fabián Alonso Alfaro-Alvarado1,2, José Vicente Rosas-Barrientos3, María Esther Ocharan-Hernández1
1Laboratorio de Modelación Bioestadística para la Salud, Sección de Estudios de Posgrado, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.
Diseases (Basel, Switzerland)
|December 22, 2023
概括
低血糖控制与老年2型糖尿病患者的肉症 (与年龄相关的肌肉损失) 有关. 这凸显了需要更好地管理糖尿病,以保持肌肉质量和功能.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 老龄化自然会减少肌肉质量,这种情况被称为sarcopenia.
- 胰岛素抵抗和高血糖症加剧老年人肌肉损失,影响力量和身体能力.
- 2型糖尿病 (T2D) 是老年人常见的疾病,通常伴有代谢失调.
研究的目的:
- 调查被诊断患有T2D的老年人肉类和血糖控制之间的关联.
- 为了确定血糖控制不良是否是这种人群中肉症的危险因素.
主要方法:
- 进行了一项涉及T2D老年人的横截面研究.
- 使用欧洲老年人肉病工作组2 (EWGSOP2) 标准诊断了肉病.
- 根据HbA1c水平,参与者被分为血糖控制 (HbA1c ≤7.5%) 和低血糖控制 (HbA1c ≥7.5%) 组.
主要成果:
- 患有肉症的老年人与没有肉症的老年人相比,血糖控制不佳的患病率更高 (62.3%),比没有肉症的老年人 (47.9%,p=0.007).
- 后勤回归显示,血糖控制不良和肉症存在之间存在显著的关联 (OR: 1.79,95% CI: 1.17-2.75).
- 较差的血糖控制也与较低的肌肉质量有关 (OR: 1.73,95% CI: 1.07-2.73).
结论:
- 较差的血糖控制与T2D的老年人中的缩症和低肌肉质量显著相关.
- 这些发现强调了优化血糖控制的重要性,以减轻这一人口群体的肌肉损失.
- 实施增强的糖尿病治疗策略可能有助于保持老年人的肌肉质量和身体功能.
更多相关视频
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
553
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
553
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Carbohydrate Metabolism
11.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.2K
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
Overview of Carbohydrate Metabolism
1.1K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.1K
Diabetes: Management and Pharmacotherapy
288
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
288


