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甲状腺激素和线粒体功能障碍:对代谢功能障碍相关的性肝病 (MASLD) 的治疗影响

Raghu Ramanathan^1,2, Sohum A Patwa¹, Ahmad Hassan Ali^1,2

¹Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65212, USA.

|December 22, 2023

概括

与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球25%的人口. 甲状腺激素 (TH) 疗法通过改善线粒体功能来治疗MASLD具有前景.

科学领域:

肝病学和代谢疾病
线粒体生物学线粒体生物学
内分泌学在内分泌学.

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是一种普遍的疾病,影响全球25%的人口.
MASLD是肝衰竭的日益严重的原因,目前还没有批准的治疗方法,需要紧急的治疗开发.
久坐不动的生活方式和不良饮食对MASLD的流行有很大影响,特别是在西方国家.

研究的目的:

审查线粒体功能障碍在MASLD病变发生中的作用.
探索甲状腺激素 (TH) 和其类似物作为MASLD治疗剂的潜力.
突出基于TH的MASLD疗法的创新药物开发计划.

主要方法:

文献综述侧重于MASLD中的线粒体功能障碍.
分析甲状腺激素 (TH) 在调节线粒体功能的作用.
对MASLD的基于TH的疗法进行的临床前和临床研究的审查.

主要成果:

线粒体功能障碍,可能涉及损伤的线粒体,是MASLD发展的关键因素.
甲状腺激素 (TH) 调节线粒体生物发生和肝细胞中的功能.
TH,TR-β类似物和肝脏特异性合成类似物显示出对MASLD的治疗潜力.

结论:

了解TH在增强线粒体功能的作用,为MASLD提供了一种新的治疗策略.
针对线粒体功能障碍的基于TH的疗法是MASLD药物开发的有希望的途径.
通过TH类似物向线粒体通路,可以解决对MASLD治疗的未满足需求.

关键词:

粮农组织粮农组织粮农组织粮农组织.马斯尔德马斯尔德是什么意思肝脏肝脏肝脏肝脏肝脏肝脏线粒体功能障碍线粒体功能障碍甲状腺激素是甲状腺激素的一种.甲状腺激素受体是甲状腺激素受体.

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