牙状状细胞癌对息性意图免疫疗法的治疗反应
Natalia Trehan1, Angelina Debbas2, Mykaihla Sternick3
1Department of Oral Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Current oncology (Toronto, Ont.)
|December 22, 2023
概括
作为PD-1抑制剂的 pembrolizumab 在患有晚期头癌的老年患者中显示出有前途的结果. 免疫疗法提供持久的反应,可能避免手术并改善生活质量.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 老年医学 老年医学
背景情况:
- PD-1 抑制剂是复发性/转移性头角状细胞癌的标准.
- 对局部晚期疾病的第一线治疗的有效性正在研究中.
- 患有下牙平细胞癌的老年患者经常面临治疗挑战.
研究的目的:
- 在下牙平细胞癌的老年患者中报告对缓性免疫疗法的治疗反应.
- 评估 pembrolizumab 作为一线息治疗的疗效.
- 评估避免手术的可能性,并优先考虑生活质量.
主要方法:
- 三名患有下牙平细胞癌的老年患者的病例报告.
- 用单剂 pembrolizumab (一种PD-1 抑制剂) 的治疗.
- 评估临床和放射性反应,副作用和治疗持续时间.
主要成果:
- 患者1:经过3个月的 pembrolizumab 完整的反应,持续在 19 个月.
- 患者2和3:单剂 pembrolizumab 的部分反应,分别在 9 个月和 5 个月持续.
- 在所有患者中观察到最小的副作用.
结论:
- 用PD-1抑制剂进行的息免疫疗法在老年患者中显示出持久的临床反应.
- 布罗利祖马布可能是手术的可行的替代方案,改善生活质量.
- 需要在老年人群中进行进一步的研究,并进行适当的患者选择.
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