针对HER2的治疗 - - 从病理生理学到临床表现:叙述性综述
Svetoslava Elefterova Slavcheva1,2, Atanas Angelov1,2
1First Department of Internal Diseases, EC Cardiology, Faculty of Medicine, Medical University "Prof. Dr. Paraskev Stoyanov", 9000 Varna, Bulgaria.
Journal of cardiovascular development and disease
|December 22, 2023
概括
对HER2阳性乳腺癌的拉斯图祖马布治疗可以通过破坏保护信号通路而导致心脏损伤 (拉斯图祖马布诱导的心脏毒性). 了解其机制是早期检测和心脏保护的关键.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 分子心脏病学分子心脏病学
- 在瘤学瘤学.
背景情况:
- 特拉斯图祖马布是治疗 HER2 过度表达的乳腺癌的重要疗法.
- 特拉斯图祖马布诱导的心脏毒性 (TIC) 是一个重要的临床问题.
- 信息通信技术的精确机制需要进一步阐明.
研究的目的:
- 审查TIC的病理生理基础.
- 描述TIC的临床表现.
- 突出了解ICT的必要性,以改善患者的治疗结果.
主要方法:
- 对ICT现有研究的文献综述.
- 对受trastuzumab影响的分子通路的分析.
- 关于心脏功能障碍的临床数据的综合.
主要成果:
- 特拉斯图祖马布抑制NRG-1/HER2/HER4信号通路,影响心肌细胞,内皮和心脏原生细胞.
- TIC涉及免疫细胞激活,炎症和神经激素系统.
- 特拉斯图祖马布与左心室缩功能障碍,以及潜在的右心室损伤和腹功能障碍有关.
结论:
- 了解TIC的病理生理学对于早期检测和心脏保护策略至关重要.
- 需要进一步的研究来确定心脏功能障碍的时间表,以获得最佳的心脏保护时间.
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