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获得的抗醇耐药性以孤立依赖的方式改变了Candida auris中与致病性相关的特征

Flora Bohner¹, Csaba Papp¹, Tamas Takacs¹

¹Department of Microbiology, University of Szeged, 6726 Szeged, Hungary.

Journal of fungi (Basel, Switzerland)

|December 22, 2023

概括

阳光对抗真菌醇的耐药性可以在每个菌株中独特地发展. 一些耐药菌株的毒性增加,为这种新兴病原体提供了具有挑战性的治疗选择.

科学领域:

医学真菌学医学真菌学
抗微生物耐药性抗微生物耐药性
传染性疾病传染性疾病

背景情况:

黄是一种新兴的真菌病原体,以多药耐药性而闻名.
醇抗真菌耐药性限制了Candida auris感染的治疗选择.

研究的目的:

研究获得的醇耐药性对Candida auris活力,应激反应和毒性的影响.
为了比较进化醇耐药Candida auris菌株的特征.

主要方法:

从敏感的临床分离物中产生抗可纳,波萨可纳和伏利可纳的Candida auris菌株.
在各种条件下对已进化的菌株进行表型和基因型分析.
对BCY1和ERG3基因突变的研究.

主要成果:

几种进化的菌株产生了泛阿和类交叉耐药性.
一种抗泛醇菌株表现出增强的大脑组织殖民,表明没有健身成本.
在进化的菌株中发现了BCY1和ERG3的突变,每个隔离物具有独特的耐药性发展途径.

结论:

黄对三醇耐药性的发展是一个复杂的过程,受多种因素的影响.
适应性成本不是Candida auris.中耐药性发展的必然结果.
菌株特定的遗传和表型变化是Candida auris.中醇耐药的复杂发展的基础.

关键词:

C. aurisis 这种虫子抗真菌耐药性的抗真菌耐药性微观进化的微观进化有三醇的三醇.毒性毒性是一种毒性.

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