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从前,口腔微生物群:一个灰娘还是自闭症谱系障碍的主角?

Michele Mussap¹, Paola Beretta², Elena Esposito²

¹Laboratory Unit, Department of Surgical Sciences, AOU Cagliari, University of Cagliari, 09124 Cagliari, Italy.

|December 22, 2023

概括

患有自闭症谱系障碍 (ASD) 的儿童的口腔微生物组显示了蛋白质细菌的增加和细菌体的减少. 这种口腔失生症与ASD症状有关,这表明益生菌可能有所帮助.

科学领域:

微生物学微生物学
神经科学是一个神经科学.
胃肠病学胃肠病学

背景情况:

自闭症谱系障碍 (ASD) 是一种终身的神经发育状况.
口腔和肠道微生物组与大脑相互联系,可能会影响神经发育障碍.
新出现的证据表明,口腔微生物组在ASD中起着作用.

研究的目的:

审查有关口腔微生物组在ASD中的作用的观察性研究.
为了确定与ASD相关的特定微生物变化.
探索口腔失生症和ASD病原体之间的联系.

主要方法:

进行了对文献的叙事审查.
在PubMed和Cochrane图书馆搜索了过去十年出版的研究.
专注于观察性研究,调查ASD的口腔微生物组.

主要成果:

自闭症儿童表现出口腔微生物群,其中含有丰富的蛋白质细菌和枯竭的细菌群.
鼠标模型显示,口腔微生物群中有大量的Bacteroidetes.
在ASD的口腔失生症改变了代谢组,过度表达乙酸盐,酸盐和内醇,同时表达不够的丁酸盐,突出了托代谢的作用.

结论:

口腔失生症和ASD核心症状之间存在强烈的关联.
用益生菌调节口腔和肠道微生物生态系统可能会减少ASD症状的严重程度.

关键词:

自闭症谱系障碍自闭症谱系障碍孩子们的孩子们的孩子们的孩子们我们的肠道微生物群.肠大脑轴肠大脑轴有泄漏的肠道代谢生物组的代谢生物组口腔中的微生物群.

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