寻找新的生物标志物来评估COVID-19患者:一个试点研究
Nikolay V Goncharov1, Piotr P Avdonin2, Natalia G Voitenko1
1Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg 194223, Russia.
Metabolites
|December 22, 2023
概括
新的诊断指数结合了丁胆酶 (BChE) 活性和·维莱布兰德因子 (vWF) 抗原水平,可以预测COVID-19死亡率. 该指数[尿素] × [AGWF] × 1000/(BChEb × [ALB]) 显示出预测死亡率的最佳歧视力.
科学领域:
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
- 病理生理学 病理生理学
背景情况:
- 在紧急情况下评估患者的严重程度,包括传染病,需要快速评估.
- 衍生指数比单个指标更好地描述复杂综合征.
- 在COVID-19患者中,乙基胆酶 (BChE) 活性降低,·威勒布兰德因子 (vWF) 分泌量增加,导致血栓形成.
研究的目的:
- 为了确定COVID-19患者的vWF度和活性.
- 确定用于预测COVID-19死亡率的新型诊断指数.
- 为了比较个别指数和新得出的指数的预测值.
主要方法:
- 对COVID-19患者的回顾性分析 (幸存者n=77,死者n=24).
- 测量BChE活性,马隆迪甲基 (MDA) 和vWF抗原 (AGWF) 和活性 (ActWF).
- 使用生物化学标志物的新诊断指数的导出和评估.
主要成果:
- 与幸存者相比,已故患者的vWF抗原水平高出1.5倍.
- 包含vWF抗原水平的指数表现优于使用vWF活性的指数.
- 该指数[尿素] × [AGWF] × 1000/(BChEb × [ALB]) 显示出对死亡率预测的优异区分能力 (AUC = 0.91).
- 该指数[] × 1000/(BChEb × [ALB]) 也显示出良好的预测值 (AUC = 0.95).
结论:
- 衍生指数[尿素] × [AGWF] × 1000/(BChEb × [ALB]) 是COVID-19死亡率的高度有效预测指标.
- 这一指数与[] × 1000/(BChEb × [ALB]一起,需要进一步验证在诊断实验室的潜在用途.
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