相关实验视频
Updated: Jul 7, 2025

Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
肺癌早期检测的呼吸分析 - 一项临床研究
Zhunan Jia1, Velmurugan Thavasi2, Thirumalai Venkatesan1,2
1NUSNNI-Nanocore, National University of Singapore, Singapore 117411, Singapore.
呼吸分析显示了早期肺癌检测的前景. 一个由八种挥发性有机化合物 (VOC) 组成的小组在识别患者的肺癌方面表现出显著的准确性,将其与其他疾病区分开来.
科学领域:
- 生物化学 生化学
- 分析化学 分析化学
- 在瘤学瘤学.
背景情况:
- 肺癌仍然是全球癌症死亡的主要原因之一.
- 早期检测对于改善患者的治疗结果至关重要.
- 对于查和诊断,非侵入性诊断方法是非常理想的.
研究的目的:
- 调查呼吸分析对非侵入性肺癌早期检测的有效性.
- 确定特定的挥发性有机化合物 (VOC) 作为肺癌的潜在生物标志物.
- 使用呼吸分析将肺癌与结核病 (TB) 区分开来.
主要方法:
- 一项涉及肺癌患者,非肺癌对照和结核病患者的队列研究.
- 使用BIO-VOC采样器采集呼吸样本.
- 挥发性有机化合物 (VOC) 通过热溶解-气相色谱-质谱法 (TD-GC/MS) 进行分析.
- 统计分析包括OPLS-DA,克鲁斯卡尔-瓦利斯和ROC分析.
主要成果:
- 13个VOC显示肺癌患者和对照人群之间存在显著差异.
- 一个由八个VOC组成的小组在发现集中实现了0.85的AUC (灵敏度82%,特异性76%).
- 在独立队列中的验证结果为AUC为0.78 (灵敏度为78%,特异性为64%).
- 过高的化物水平与肺癌组织中过度激活的酒精脱酶 (ADH) 途径有关.
结论:
- 呼吸分析是一种有前途的非侵入性工具,用于早期检测肺癌.
- 特定的VOC档案可以有效地区分肺癌和其他疾病,包括结核病.
- 需要进一步验证以临床实施基于呼吸的肺癌诊断.
更多相关视频
08:23Real-time Breath Analysis by Using Secondary Nanoelectrospray Ionization Coupled to High Resolution Mass Spectrometry
Published on: March 9, 2018
08:34Investigation into Deep Breathing through Measurement of Ventilatory Parameters and Observation of Breathing Patterns
Published on: September 16, 2019
相关概念视频
Assessment of Respiration
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like...
Respiratory Assessment: Purpose and Indications
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Physical Assessment of the Respiratory Tract I: Health History
Subjective Data
Subjective data provides vital information about the patient's health history and symptoms. This data is typically collected through interviews in which patients describe their experiences, symptoms, and concerns.
Health history and...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Physical Assessment of the Respiratory Tract II: Inspection
Chest Configuration
The chest configuration...
Assessment of Ventilation II: Respiratory Depth and Rhythm
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement: