粘膜的合成模型用于口腔透研究
Cristina Alonso1, Meritxell Martí1, Anderson Ramos1
1Surfactants and Nanobiotechnology Department, Institute of Advanced Chemical of Catalonia of CSIC, (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.
Membranes
|December 22, 2023
概括
这项研究表明,Nuclepore合成膜有效地模拟了水和药物透的语言下粘膜透性. 这些人造膜可靠地选口服透配方.
科学领域:
- 生物材料科学 生物材料科学
- 药理动力学 药理动力学
- 膜技术 膜技术 膜技术
背景情况:
- 语言下药物输送需要了解粘膜透性.
- 评估合成膜作为粘膜模型对于有效的配方选至关重要.
- 防水配方旨在防止病毒和毒素等有害物质透.
研究的目的:
- 评估Nuclepore合成膜作为语言下粘膜透研究的模型.
- 为了比较合成和天然猪舌下粘膜之间的水和活性化合物透性.
- 评估使用两种膜类型的防水配方的有效性.
主要方法:
- 通过核孔和猪舌下粘膜对水的比较透性研究.
- 用防水配方修改的膜的评估.
- 活性化合物,药物和生物杀菌剂通过两种膜类型的透性研究.
- 膜间跨粘膜流失 (TMWL) 的相关性分析.
主要成果:
- 在合成膜和天然膜的跨粘膜流失 (TMWL) 之间发现了很高的相关性 (R2=0.88).
- 与粘膜相比,合成膜显示了类似的咖啡因透概况,即使使用了防水剂.
- 与天然的粘膜相比,合成膜对不同的透物具有较低的选择性.
结论:
- 核孔合成膜是用于选口腔透配方的水透性的合适模型.
- 合成膜可用于对抗病毒和毒素透的防水配方的初步评估.
- 该模型支持开发和选用于口腔或舌下粘膜应用的配方.
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