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酸辅助的Mytilus edulis水解剂:一种营养方法,用于从肌肉缩中恢复

R P G S K Amarasiri¹, Jimin Hyun¹, Sang-Woon Lee¹

¹Department of Marine Life Science, Jeju National University, Jeju 63243, Republic of Korea.

|December 22, 2023

概括

酶辅助的Mytilus edulis水解酸 (AMH) 通过促进细胞生长和肌肉蛋白质合成,有效地对抗肌肉缩. 这种新的方法在改善肌肉健康和功能方面表现有前途.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
身体生理学身体生理学

背景情况:

肌肉缩是一种衰弱的疾病,源于诸如衰老和疾病等多种因素,显著损害生活质量.
目前的干预措施,如运动,对于卧床的人来说是有限的,需要替代策略.
与运动一起的营养补充剂为管理肌肉缩提供了一个有希望的途径.

研究的目的:

研究Mytilus edulis的酶辅助水解剂在预防和治疗肌肉缩方面的疗效.
为了比较使用Protamex,Alcalase和Flavourzyme制备的水解剂的影响.
在德克萨米他诱导的肌肉缩模型中评估最有效的水解剂.

主要方法:

使用Protamex (PMH),Alcalase (AMH) 和Flavourzyme (FMH) 制备Mytilus edulis的水解物.
在体外评估使用C2C12细胞核细胞来评估细胞增殖,髓管形成和蛋白质表达.
在甲诱导的肌肉缩斑马鱼模型中的体内评估,以评估运动能力和体重.

主要成果:

酶辅助的M. edulis水解剂 (AMH) 显示出优异的蛋白质回收率 (57.06%) 和氨基酸含量.
艾美显著增强了C2C12细胞增殖,肌管直径和覆盖范围.
在体外,AMH治疗降低了与缩相关的蛋白质 (E3无素连接酶) 和增加了缩标志物 (myogenin,MyHC).
在斑马鱼肌肉缩模型中,AMH改善了运动运动活动和体重.

结论:

酶辅助的M. edulis水解剂 (AMH) 是一种高度有效的治疗肌肉缩的方法.
AMH促进肌肉细胞生长和蛋白质合成,减轻肌肉损耗.
亚米显示出作为治疗肌肉缩恢复的治疗剂的显著潜力.

关键词:

阿尔卡拉斯 (Alcalase) 是一种类植物.这种植物是Mytilus edulis.蓝贝是什么意思蓝贝是什么意思海洋生物资源是海洋生物资源.肌肉缩肌肉缩肌肉缩营养补充剂营养补充剂

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