分层双氧化物作为疏水分子的间隙系统
Lei Li1,2, Anastasia Sevciuc1,2, Patrick van Rijn1,2
1Department of Biomedical Engineering-FB40, University of Groningen, University Medical Center Groningen, Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Nanomaterials (Basel, Switzerland)
|December 22, 2023
概括
这项研究展示了一种新的方法,使用二硫酸盐 (SDS) 将疏水性药物加载到分层双氧化物 (LDH) 中. 优化的间隔系统显著提高了LDHs对疏水化合物的药物加载效率.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 层状双氧化物 (LDH) 以其生物相容性和受控释放特性而闻名,使其成为有前途的药物载体.
- 目前的研究主要利用LDH用于阳离子药物,对疏水性药物输送的探索有限.
- 开发有效的方法来将疏水性药物装入LDH是扩大其治疗应用的关键.
研究的目的:
- 开发和优化一种将疏水性药物装入LDHs的方法.
- 调查二硫酸盐 (SDS) 作为疏水性药物间隔的中间体的作用.
- 为了确定最大限度地提高药物加载效率,最优的SDS/NR比.
主要方法:
- 利用尼罗河红色 (NR) 作为一种疏水性药物模仿剂.
- 使用二甲基硫酸盐 (SDS) 作为NR中介存储介质,用于NR插入LDHs.
- 优化了实验条件,并系统地改变了SDS/NR摩尔比率 (2/1到32/1).
主要成果:
- 通过使用SDS,成功地将恐水药模仿剂尼罗河红色 (NR) 插入LDHs.
- 对于NR的LDH-SDS-NR的负载效率随着SDS/NR的摩尔比率而变化,在32/1比率上达到6.31%.
- 装载效率从1.32% (2/1比率) 提高到4.46% (8/1比率),在最终增加之前略有下降.
结论:
- 开发的方法可以有效地将疏水性药物装入LDH中.
- 这项研究扩大了LDHs作为疏水化合物的多功能药物递送系统的潜在应用.
- 这些发现有助于在制药和生物医学领域更广泛地利用LDH.
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