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从Wnt-1/β-catenin通路中增加CK14的免疫表达在牙瘤的发展过程中
Glória Maria de França1, Leonardo Magalhães Carlan1, Hévila de Figueiredo Pires1
1Postgraduate program of Dental science, Concentration area in Stomatology and Oral Pathology, Federal University of Rio Grande do Norte, Brazil.
Brazilian dental journal
|December 22, 2023
概括
细胞激素14 (CK14) 在牙发育和牙瘤形成中起着至关重要的作用. 这种蛋白质在牙生长表皮质中表达很高,特别是在牙胚芽早期阶段和牙瘤病变中.
科学领域:
- 发育生物学是发展生物学.
- 口腔病理学 口腔病理学
- 分子信号传递是分子信号传递.
背景情况:
- 牙发育是一个复杂的过程,由表皮-介质酶相互作用驱动.
- 包括Wnt-1/β-catenin在内的异常信号通路与牙瘤的发展有关.
- 在这些过程中,Cytokeratin 14 (CK14) 的作用仍然不完全理解.
研究的目的:
- 研究CK14在人类牙形成中的表达和作用.
- 分析CK14与Wnt-1/β-catenin信号传递在牙发育中的关联.
- 为了确定CK14的免疫表达在odontoma的odontogenic上皮细胞.
主要方法:
- 横截面,回顾性免疫组织化学分析.
- 评估了30种复合性牙瘤,30种复杂性牙瘤和17种牙细菌.
- 在组织样本中评估CK14,Wnt-1和β-catenin蛋白表达.
主要成果:
- 在牙细菌和牙瘤的质细胞中发现了显著更高的CK14免疫表达.
- Wnt-1和β-catenin在牙胚芽上皮细胞和牙瘤内皮细胞中显示出更高的免疫表达.
- CK14表达在早期牙胚芽阶段 (芽,盖) 升高,在钟阶段降低;牙瘤显示Wnt-1/β-catenin减少,但在矿物质材料附近的上皮细胞中增加了CK14.
结论:
- 在牙发育过程中,CK14在odontogenic表皮和牙瘤中高度表达.
- CK14的表达与Wnt-1/β-catenin信号相关,这表明它参与了牙生成和牙瘤的发病.
- 改变的CK14和Wnt-1/β-catenin表达模式可能有助于在牙瘤中观察到的异常牙结构.
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