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持续流动心室辅助器件支持器件的患者中循环中性粒细胞的细胞酶能力增加

Morcos A Awad¹, Wenji Sun¹, Dong Han¹

¹Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Artificial organs

|December 22, 2023

概括

持续流动心室辅助装置 (CF-VAD) 的支持增加了中性粒细胞激活和细胞容量. 炎症性细胞因子持续升高数周,这表明VADs诱导了先发性细胞性中性粒细胞表型.

科学领域:

免疫学免疫学免疫学
心血管外科心血管外科
生物医学工程生物医学工程

背景情况:

中性粒细胞是关键的先天性免疫细胞,参与着细胞和细胞因子释放.
持续流 (CF) 室腔辅助器件 (VAD) 的患者中性粒细胞的细胞功能尚不清楚.

研究的目的:

研究CF-VAD植入物对中性粒细胞功能和炎症标志物的影响.

主要方法:

来自14名CF-VAD患者的血液样本在手术前和手术后的3,7,14,28天被分析.
流细胞计评估了中性粒细胞表面标记物和细胞容量.
与酶相关的免疫吸收剂测试测量了炎症性细胞因子和中性粒细胞酶的血水平.

主要成果:

中性粒细胞激活标志物和促炎性细胞因子 (IL-6,IL-8,TNF-α) 在VAD植入后增加,在7-14天内保持升高.
中性粒细胞的吞细胞能力在术后28天内显著升高.
在患有和没有手术前VAD支持的患者中观察到类似的模式.

结论:

持续流动的VAD支持增强了中性粒细胞激活和细胞能力.
炎症性细胞因子的升高表明持续的炎症反应长达两周.
植入VAD可能会在循环中性粒细胞中诱导一种先发性细胞表型.

关键词:

连续流动心室辅助器件连续流动心室辅助设备炎症性细胞因子是炎症性细胞因子.中性粒细胞中性粒细胞.发细胞症 (phagocytosis) 是一种致死细胞的发生.

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