早期断奶牛犊中Baccharis coridifolia的中毒:病理学研究和新的宏循环三甲烯鉴定
Mizael Machado1, Rafael Martínez2, Sol Andres3
1Plataforma de Investigación en Salud Animal (PSA), Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental Tacuarembó, Tacuarembó 45000, Uruguay.
Toxins
|December 22, 2023
概括
两个牛犊中毒疫情与Baccharis coridifolia有关. 有毒的宏环三甲,包括新型马洛尼尔-葡萄糖合物,在受影响的小牛中引起严重的组织损伤和高死亡率.
科学领域:
- 兽医毒理学 兽医毒理学
- 植物毒理学 植物毒理学
- 动物病理学 动物病理学
背景情况:
- 巴卡里斯·科里迪维利亚 (Baccharis coridifolia) 的中毒是畜牧业的一个重大问题.
- 早期断奶的牛肉小牛特别容易受到植物引起的毒性.
- 了解有毒化合物和病理影响对于预防至关重要.
研究的目的:
- 为了调查Baccharis coridifolia在牛肉小牛中发生的两起疫情中毒.
- 为了确定导致中毒的有毒化合物.
- 描述病理发现和超结构变化的特征.
主要方法:
- 对受影响的小牛进行临床和病理检查.
- 皮上皮细胞的超结构分析.
- 液体染色学-质谱学 (LC-MS) 用于毒素识别和量化.
主要成果:
- 34只小牛表现出唾液,厌食症,脱水和腹,死亡率分别为37.5%和43.3%.
- 前胃和淋巴组织的亡是主要的病理发现.
- LC-MS确定了56种宏环三甲基,包括新型马洛尼尔-葡萄糖合物,在1.2 ± 0.1 mg/g的植物物质中.
结论:
- Baccharis coridifolia被证实是牛肉小牛自发中毒的原因.
- 宏环三合甲基,包括新的马洛尼尔-葡萄糖合物,是致病剂.
- 已识别的毒素诱导严重的胃肠道和淋巴组织损伤,导致高死亡率.
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