毒素治疗与癌症有关的疾病:系统性审查
Delaram Safarpour1, Bahman Jabbari2
1Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
Toxins
|December 22, 2023
概括
肉毒神经毒素 (BoNT) 疗法有效地减少疼痛,并预防癌症手术后的胃衰和面部出汗等并发症. 这篇评论突出了BoNT的重点.
科学领域:
- 在瘤学瘤学.
- 神经外科 神经外科
- 胃肠病学 胃肠病学
背景情况:
- 癌症治疗,包括手术和放射治疗,可以导致严重的疼痛和功能障碍.
- 肉毒神经毒素 (BoNT) 越来越多地被探索用于管理癌症疗法的副作用.
- 需要对BoNT在治疗癌症相关并发症方面的有效性进行系统审查.
研究的目的:
- 系统地审查有关肉毒神经毒素 (BoNT) 治疗癌症相关疾病的现有文献.
- 评估BoNT在缓解疼痛,预防胃衰竭,控制面部出汗和治疗癌症后囊手术中的有效性.
- 为了比较BoNT治疗与癌症相关并发症的其他干预措施.
主要方法:
- 系统的文献搜索研究研究在癌症患者中进行肉毒神经毒素 (BoNT) 治疗.
- 包括报告疼痛管理,胃衰竭预防,口味过,囊和疼痛的研究.
- 对研究结果的分析,比较BoNT干预与安慰剂,没有干预或替代性手术/医疗治疗.
主要成果:
- 在所有13项审查的研究中,BoNT注射显著减少或消除了手术或辐射部位的疼痛.
- 在食道癌手术后,BoNT注射到胆管中显示出有前途的预防胃衰竭,在12项研究中,有8项研究发现它优于没有干预.
- 博恩特疗法在减少口腔切除术后面部出汗 (口味性过),预防 (弗雷综合征) 和缓解下疼痛 (第一次咬伤综合征) 中有效.
结论:
- 肉毒神经毒素 (BoNT) 治疗在治疗各种与癌症相关的疾病,包括疼痛,胃衰竭和术后并发症方面表现出显著的疗效.
- 对于某些并发症,如胃衰竭,BoNT为外科干预提供了一个潜在的更安全的替代方案.
- 进一步的研究可能会巩固BoNT作为瘤支持护理中宝贵的治疗选择的作用.
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