维诺雷尔宾作为第四阶段犬原发性肺癌的第一线治疗
Valentina Rinaldi1, Riccardo Finotello2, Andrea Boari1
1Department of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.
Veterinary sciences
|December 22, 2023
概括
维诺雷尔宾 (VRL) 在治疗犬肺癌方面表现有前途,10只狗中有8只出现部分反应. 这种葡萄酒类化合物耐受性良好,可能是狗中晚期肺癌的宝贵一线治疗选择.
科学领域:
- 兽医瘤学 兽医瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 维诺雷尔宾 (VRL) 是一种半合成的葡萄酒类化合物,用于治疗人类肺癌.
- 在犬类中,VRL显示出高肺组织度,抗瘤活性,以及有利的毒性概况.
研究的目的:
- 评估维诺雷尔 (VRL) 作为狗晚期肺癌的第一线治疗方法的疗效和安全性.
主要方法:
- 十只先前没有接受过治疗的,患有晚期肺癌的狗每周接受维诺雷尔宾 (15 mg/m2) 4 周,然后每两周一次.
- 使用RECIST标准通过诊断成像来评估瘤反应,毒性由VCOGC组分级.
主要成果:
- 十分之八的狗实现了部分反应.
- 病情进展的中位时间为88天,中位生存时间为100天.
- 中性是最常见的副作用;VRL通常耐受良好.
结论:
- 维诺雷尔宾 (VRL) 具有足够的毒性概况,在治疗狗的晚期肺瘤方面具有潜在的有效性.
- VRL可以作为狗肺癌的有益的第一线治疗策略.
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