流行病学,分子致病性,免疫致病性,免疫逃生机制和疫苗评估为HPV相关的致癌性
Meenu Jain1, Dhananjay Yadav2, Urmila Jarouliya3
1Department of Microbiology, Viral Research and Diagnostic Laboratory, Gajra Raja Medical College, Gwalior 474009, Madhya Pradesh, India.
Pathogens (Basel, Switzerland)
|December 22, 2023
概括
人类乳头瘤病毒 (HPV) 导致大多数宫癌. 本综述涵盖了HPV病毒.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 人类乳头瘤病毒 (HPV) 是导致子宫癌的主要原因,其患病率受到基因型,疫苗接种状态和样本位置的影响.
- 类型16和18的HPV与各种癌症有关,包括宫癌,门癌和口癌.
- 瘤性HPV进展涉及瘤微环境中的共感染,生活方式因素和免疫反应.
研究的目的:
- 审查HPV感染在癌症进展中的作用.
- 探索HPV相关癌症的分子和免疫病原发生.
- 讨论宿主免疫反应,病毒免疫逃避,疫苗接种和预防策略.
主要方法:
- 关于HPV感染,癌症进展和免疫病原发生的文献综述.
- 影响HPV患病率和病理学的因素分析.
- 检查分子机制,宿主免疫力和病毒逃避策略.
主要成果:
- 超过90%的宫癌都与HPV有关,其中特定的基因型驱动着瘤发生.
- 包括生活方式和免疫反应在内的多个因素有助于HPV诱导的癌症发展.
- 病毒逃避免疫监测促进HPV的持久性.
结论:
- 对于高风险的HPV类型,存在有效的预防性疫苗.
- 疫苗接种意识和预防战略对于减少HPV感染和相关癌症至关重要.
- 了解HPV在癌症中的复杂作用对于开发有效的控制措施至关重要.
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