具有抗微生物活性的创新弹性体可能会降低哺乳期感染风险.
Gabriele Meroni1, Valerio Sora1,2, Francesca Zaghen1,2
1Department of Biomedical, Surgical and Dental Sciences-One Health Unit, School of Medicine, University of Milan, Via Pascal 36, 20133 Milan, Italy.
Pathogens (Basel, Switzerland)
|December 22, 2023
概括
基本的材料表现出内在的抗菌活性,减少病原体在奶牛群中传播. 新的抗微生物弹性体显著降低了细菌负载,有助于乳制品的可持续性和One Health目标.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 材料科学 材料科学 材料科学
- 微生物学 微生物学
背景情况:
- 奶牛群中的传染病原体带来了重大的经济和动物感染风险,而抗菌素耐药性则加剧了这种风险.
- 哺乳过程,特别是污染,是牛之间的病原体传播的主要载体.
- 当前的感染控制协议通常需要隔离,缺乏有效的非隔离方法.
研究的目的:
- 为了评估乳制品内的新型弹性体配方的抗菌疗效.
- 研究和弹性体的内在抗菌性质.
- 评估抗微生物添加剂对奶期间病原体减少的影响.
主要方法:
- 测试两种弹性体类型 (,) 和九种配方对主要乳腺炎病原体 (金黄色杆菌,Streptococcus agalactiae,大肠杆菌) 的检测.
- 挑战弹性体样本与细菌培养,以量化病原体的生存率.
- 分析细菌生存曲线以确定抗微生物活性.
主要成果:
- 基本弹性体表现出对测试的病原体具有固有的抗菌活性.
- 弹性体显示出一些抗菌能力,但低于.
- 所有含有抗微生物成分的测试配方都显著降低了细菌生存率.
- 疗效的变化归因于配方和制造工艺的差异.
结论:
- 新型抗微生物弹性体提供了一个有前途的解决方案,以减少通过奶的病原体传播.
- 的本质抗菌性质为动物健康领域的材料开发提供了新的途径.
- 这些进步支持奶牛群的可持续性,并通过减轻动物传播疾病和抗菌药物的使用,与One Health原则保持一致.
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