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异种食作为一种策略,用于在1型或2型麻风病反应期间消除Mycobacterium leprae:系统性审查

Débora Dantas Nucci Cerqueira^1,2, Ana Letícia Silva Pereira¹, Ana Elisa Coelho da Costa¹

¹Department of Immunology, Keizo Asami Institute-iLIKA, Federal University of Pernambuco-UFPE, Recife 50670-901, Pernambuco, Brazil.

Pathogens (Basel, Switzerland)

|December 22, 2023

概括

麻风病反应涉及复杂的免疫反应. 本综述探讨了细胞过程异如何影响1型反应期间的Mycobacterium leprae消除,揭示了对比的机制.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
微生物学微生物学

背景情况:

麻风病是由*Mycobacterium leprae*引起的,它会影响巨细胞和施万细胞.
麻风反应 (T1R和T2R) 是对菌根细菌抗原的炎症反应.
在麻风反应期间,外来食物在消除*M. leprae*中的作用尚未完全理解.

研究的目的:

为了审查自和 *M. leprae* 消除在麻风反应期间的关系.
为了阐明在麻风病中异食症的免疫机制.

主要方法:

在PubMed/Medline,Scopus和ScienceDirect数据库中的系统文献搜索.
适用了资格标准,并选择了在2023年8月进行独立同行评审的文章.

主要成果:

包括八项研究,揭示了1型反应 (T1R) 发展的二分法.
在进展到T1R的多菌株患者中,观察到异细胞阻断和炎症酶激活 (IL-1β).
相反,一些研究表明,在T1R之前,IL-15的增加,IFN-γ的产生和异食诱导.

结论:

在1型麻风病的反应发展中存在一个关于异食症的二分法.
没有发现调查异口症在2型麻风反应中的研究.

关键词:

这是一种Mycobacterium leprae细菌.自自是自的过程.麻风的反应麻风反应异种食 (Xenophagy) 是一种外来食.

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