结合金属和PFAS与心血管疾病风险的关联
Yvonne S Boafo1,2, Sayed Mostafa3, Emmanuel Obeng-Gyasi1,2
1Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.
Toxics
|December 22, 2023
概括
对金属和和多基物质 (PFAS) 的联合暴露显著增加了心血管疾病 (CVD) 的风险. 特别是暴露对各种心血管疾病标志物产生了重大影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管疾病流行病学
背景情况:
- 金属和per-和多基物质 (PFAS) 是常见的环境污染物.
- 以前的研究表明,个别污染物可能会影响心血管健康.
- 这些共同暴露对心血管疾病 (CVD) 风险的综合影响仍然不太清楚.
研究的目的:
- 研究金属和PFAS对心血管疾病 (CVD) 风险的综合影响.
- 确定特定的金属和PFAS,这些金属和PFAS在共同暴露时对心脏病风险贡献最大.
- 分析污染物混合物与各种心血管疾病风险标志物之间的关系.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2007-2014).
- 评估个人心血管疾病标志物 (血压,脂质) 和复合风险评分 (OCBI,弗雷明汉风险评分).
- 使用线性回归和贝叶斯内核机器回归 (BKMR) 来分析多重污染物暴露和相互作用.
主要成果:
- 对金属和PFAS的联合暴露与心血管疾病风险增加有关.
- 与相关的同时暴露对许多心血管疾病相关标志物产生了最显著的影响.
- 分析了特定的PFAS (PFOA,PFOS,PFNA,PFHxS) 和金属 (Pb,Cd,Hg) 的情况.
结论:
- 对环境金属和PFAS的联合暴露显著增加了心血管疾病的风险.
- 了解多重污染物暴露的协同效应对于心血管健康至关重要.
- 公共卫生战略应考虑这些污染物的累积影响.
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