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互白蛋白6和17的遗传多态性与顶端牙周炎相关:一个横截面研究
Rebeka Thiara Nascimento Dos Santos1, Luísa Priscilla Oliveira de Lima2, Maria Tereza Cartaxo Muniz2
1Departament of Stomatology and Oral and Maxilofacial Patology, University of Pernambuco, Recife, Pernambuco, Brazil.
Brazilian dental journal
|December 22, 2023
概括
在患有角牙周炎的患者中,分析了6号和17号介质素的遗传多态性. 观察到这些多形态的高频率,但它们与较大的周围损伤大小没有相关性.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 免疫遗传学 免疫遗传学
- 口腔病理学 口腔病理学
背景情况:
- 互白蛋白6和17在内牙感染期间参与骨质再吸收.
- 这些介质蛋白中的遗传多态性可能会影响周周病变大小和骨损失.
- 牙顶部牙周炎,包括无症状的牙顶部牙周炎和慢性牙顶部,是一种常见的内牙疾病.
研究的目的:
- 在无症状顶端牙周炎或慢性顶端腹患者中确定介质素6 (IL-6) 和介质素17 (IL-17) 基因多态的频率.
- 调查周周病变区域与患者年龄,性别以及IL-6和IL-17多态的存在之间的潜在相关性.
- 评估这些遗传变异在内牙疾病进展的背景下具有临床意义.
主要方法:
- 研究人群:30人被诊断患有无症状的牙牙炎或 Pernambuco 的慢性牙.
- 基因定型:聚合酶连锁反应限制片段长度多态性 (PCR-RFLP) 对于IL-6 (rs 1800795) 和IL-17 (rs 2275913).
- 统计分析:费舍尔的精确,奇平方,赔率比,逻辑回归和线性回归测试 (p ≤0.05%).
主要成果:
- 在大型周周病变的发生与年龄,性别或诊断之间没有发现统计学上显著的相关性.
- 对于IL-6和IL-17多形态的等位基因分布,研究组之间没有显著差异.
- 在受研究的人群中观察到高频率的IL-6和IL-17的同和异多态.
结论:
- 研究中介素6和介质素17的多态性与无症状周围炎症病变的增加面积没有统计相关.
- 在这种人群中,IL-6和IL-17的遗传变异可能不是围性病变大小的主要决定因素.
- 可能需要对更大的队列进行进一步的研究,以充分阐明这些遗传因素在内牙疾病结果中的作用.
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