相关实验视频
Updated: Jun 27, 2026

11:19
Oral Biofilm Formation on Different Materials for Dental Implants
Published on: June 24, 2018
11.5K
天然化合物对牙表面的物理化学影响和细胞行为
Patricia Milagros Maquera-Huacho1,2, Gabriel Garcia de Carvalho1,2, Miguel Jafelicci Júnior3
1Department of Physiology and Pathology, School of Dentistry, São Paulo State University(Unesp), Araraquara, SP, Brazil.
Brazilian dental journal
|December 22, 2023
概括
表面的卡瓦克罗尔和特尔皮-4-ol去污染可以保存细胞相互作用以进行重新骨质整合. 赫西丁对表面特性和细胞活力产生负面影响,阻碍愈合.
科学领域:
- 生物材料科学 生物材料科学
- 表面化学 表面化学
- 细胞生物学 细胞生物学
背景情况:
- (Ti) 广泛用于牙科和骨科植入物.
- 表面净化对于植入成功和骨质整合至关重要.
- 评估新型除污剂,如卡瓦克罗尔和特尔皮宁-4-ol是必不可少的.
研究的目的:
- 评估卡瓦克罗尔 (Cvc),烯-4-ol (T4ol) 和赫西丁 (CHX) 对表面性能的影响.
- 评估这些治疗对纤维细胞和骨质细胞活力,增殖,粘附和扩散的体外影响.
- 为了确定Cvc和T4ol在重新骨质整合的背景下适用于表面净化.
主要方法:
- 表面被Cvc,T4ol,CHX,DMSO或超纯水 (控制) 处理.
- 表面可湿度,表面自由能量 (SFE),扫描电子显微镜 (SEM) 和能量分散谱法 (EDS) 用于物理化学分析.
- 在24小时和72小时化后,通过Alamar蓝色测定和光显微镜评估了细胞活力,粘附和扩散.
主要成果:
- Cvc和T4ol处理导致表面上存在Na,O和Cl.
- 所有测试的表面都表现出水友特性,SFE值在3.4至5.5mN/m之间.
- 通过EDS,CHX治疗显示出O和Cl峰值,并显著降低了细胞活力和表面的粘附.
结论:
- 用卡瓦克罗和特尔皮-4-ol对表面的净化不会对表面的性能产生负面影响.
- Cvc和T4ol治疗支持与纤维细胞和骨质细胞的适当相互作用,这对于重新骨质整合至关重要.
- 赫西丁去污染对的表面特性和细胞反应产生不利影响,可能会损害骨质整合.
相关概念视频
The Bone Matrix
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Essential Minerals for Bone Health
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Effects of Chemicals: Overview
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
Complexation Equilibria: The Chelate Effect
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
EDTA: Chemistry and Properties
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
Complexometric Titration: Ligands
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...

