时间范围与1型糖尿病成年人糖尿病视网膜病变的发生有关:一项纵向研究
Viral N Shah1, Lauren G Kanapka2, Halis K Akturk1
1Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Diabetes technology & therapeutics
|December 22, 2023
概括
持续血糖监测 (CGM) 的指标,如范围内的时间和范围以上的时间,与1型糖尿病的糖尿病视网膜病变 (DR) 风险有关. 更严格的血糖控制可能有助于预防DR的进展.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 代谢疾病 代谢疾病
背景情况:
- 糖尿病视网膜病变 (DR) 是1型糖尿病视力丧失的主要原因.
- 持续的葡萄糖监测 (CGM) 提供了超出HbA1c的详细血糖洞察力.
- CGM指标与事件DR之间的关联需要进一步调查.
研究的目的:
- 评估CGM衍生的血糖指标与1型糖尿病成年人DR发病率之间的关系.
- 为了确定不同葡萄糖范围中的时间是否预测未来的DR发展.
主要方法:
- 对1型糖尿病成年人CGM数据的回顾性分析.
- 包括发生DR的患者和没有DR的对照组.
- 用于评估CGM指标和事件DR之间的关联的物流回归模型,调整共变量.
主要成果:
- 发生DR的几率增加与更高的HbA1c,平均葡萄糖和超出范围 (TAR) 的时间有关.
- 目标范围 (TIR) 的时间减少和目标范围 (TITR) 的时间减少也与更高的DR风险相关.
- CGM指标 (TIR,TITR,TAR,平均葡萄糖) 显示了相互之间强烈的相关性 (≥0.97).
结论:
- 包括TIR,TITR和TAR在内的CGM指标是1型糖尿病中DR风险的重要预测指标,类似于HbA1c.
- 这些高度相关的CGM指标提供了关于血糖控制和DR风险的有价值信息.
- 优化目标葡萄糖范围中的时间可能对预防1型糖尿病的DR至关重要.
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