糖化血红蛋白与儿童群体的时间范围之间的关系
Mathilde Vandenbempt1, Hanne Matheussen2, Sara Charleer3,4
1Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
Diabetes technology & therapeutics
|December 22, 2023
概括
时间范围 (TIR) 与1型糖尿病儿童的糖化血红蛋白 (HbA1c) 有很强的相关性. 短期TIR测量是评估血糖控制的长期测量的可行替代方案.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 糖化血红蛋白 (HbA1c) 是1型糖尿病 (T1D) 管理的标准指标.
- 时间范围 (TIR) 是评估T1D的血糖控制的一个新兴指标.
- 在儿科T1D中短期TIR的实用性需要进一步研究.
研究的目的:
- 确定儿科T1D中不同时间间隔 (2,4周和12周) 的HbA1c和TIR之间的相关性.
- 在这个人群中评估TIR作为HbA1c的补充指标.
- 为了评估TIR和超范围时间 (TAR) 之间的相关性.
主要方法:
- 追溯的单中心队列研究.
- 包括168名患有T1D的儿童.
- 收集持续的葡萄糖监测数据,HbA1c和人口变量.
主要成果:
- 在2,4和12周的时间内,在HbA1c和TIR之间观察到强烈的线性相关性 (R值从-0.571到-0.624不等).
- 在短期TIR (TIR2w) 和长期TIR (TIR12w) 之间发现了很高的相关性.
- 在HbA1c和时间超出范围 (TAR) 之间以及TIR和TAR之间发现了显著的相关性.
结论:
- TIR是一种与HbA1c有很强的相关性和潜在的补充性指标,用于评估儿科T1D的血糖控制.
- 短期TIR (TIR2w) 是长期TIR (TIR12w) 的一个可行的替代方案.
- 时间超出范围 (TAR) 显示出承诺,作为血糖控制的额外指标.
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