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Updated: Jul 7, 2025

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs
11:12

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs

Published on: March 9, 2013

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设计,合成和生物化学分析的分子,旨在增强内体逃生

Satish G Jadhav1,2, Ryan L Setten1,3, Carlos Medina1,4

  • 1Department of Cellular & Molecular Medicine, UCSD School of Medicine, 9500 Gilman Dr, MC0686, La Jolla, California, 92093-0686, USA.

The AAPS journal
|December 22, 2023
PubMed
概括

科学家们设计了一个通用内体逃生域 (uEED),以帮助RNA疗法克服细胞障碍. 这种以病毒为灵感的仿生方法,通过使癌症和COVID-19等疾病的治疗能够通过内体逃生来增强药物输送,从而提高了药物输送效率.

关键词:
对于RNA疗法来说,它是非常重要的.细胞内体逃生域 (endosomal escape domain) 是一种内体逃生域.提供寡核酸的输送.

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