在冠状动脉疾病的反应转移.
Oluwaseyi A Lawal1, Oluwagbohunmi A Awosoga2, Maria J Santana1
1Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada.
概括
响应转移显著影响患者报告的冠状动脉疾病 (CAD) 在重血管化后的结果. 调整响应转移 (RS) 对于准确评估CABG,PCI或OMT接受CAD患者的治疗效果至关重要.
科学领域:
- 心脏病学 心脏病学
- 健康 结果 研究 研究 结果
- 心理测量 心理测量 心理测量
背景情况:
- 冠状动脉疾病 (CAD) 显著影响患者的生活质量,往往需要超出最佳医疗疗 (OMT) 的干预措施.
- 患者报告的结果 (PROs) 对于评估治疗有效性至关重要,但这些结果的变化可以受到响应转移 (RS) 的影响.
研究的目的:
- 评估响应转移 (RS) 对冠状动脉疾病 (CAD) 患者在不同治疗策略中的患者报告结果 (PRO) 的影响.
- 评估RS如何影响痛症状和重血管化手术后的负担变化的解释,与单独OMT相比.
主要方法:
- 利用了来自阿尔伯塔省冠心病结果评估项目 (APPROACH) 登记册的数据,其中包括3116名冠心病患者.
- 采用多组确认因子分析 (MG-CFA) 来评估跨治疗组的RS测量不变性和RS测试 (冠状动脉旁路移植 [CABG],皮肤冠状动脉干预 [PCI]和OMT) 在血管造影后2周和1年.
- 用西雅图心痛问卷 (SAQ-CAN) 的16项加拿大版本来测量PROs.
主要成果:
- 两周后,MG-CFA证实了治疗组之间的部分强不变.
- 在Angina Symptoms and Burden子尺度上检测到重新校准RS,其大小为0.32 (OMT),0.28 (PCI) 和0.53 (CABG).
- 在对RS进行调整后,在CABG组中观察到PRO的最大改善,而在OMT组中则可以忽略不计的改善.
结论:
- 在使用SAQ-CAN评估CAD患者的PRO变化时,建议调整响应转移 (RS).
- 准确评估治疗效应,特别是将复血管化策略 (CABG,PCI) 与OMT进行比较,需要考虑RS.
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